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To view a copy of this licence, visit About this article Cite this article Bonomi, M., Balsamo, A., Bizzarri, C

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In contrast to many other peptide hormones, IGFs are avidly bound to specific IGFBPs, which significantly increases the half-life of IGF-1 in circulation.The seven classes of IGFBPs which are known at present 1,3,4 either bind IGF-1 and IGF-2 with similar affinities or show a preference for IGF-2